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The Dutch defender emerged as the initial backline player to net twice in a English top-flight match for Tottenham since the Belgian defender in March 2013.
Key points
Micky Van de Ven nods home two times in opening period
The home side's Jake O'Brien has goal disallowed after VAR review
Senegalese midfielder nets final goal in 89th minute
This loss is Everton's first at Hill Dickinson Stadium
Micky van de Ven found the net twice as Spurs extended their unbeaten run on the road in the top division and delivered Everton their initial loss at Hill Dickinson Stadium.
The Toffees were undefeated in their five previous fixtures at their new ground at Bramley-Moore Dock, having left Goodison Park behind after more than a century at the end of last season.
But Spurs captain the Dutchman pounced on two occasions from corners in the first half to put their strong form at risk, and they were unable to turn it around before Pape Matar Sarr - set up by ex-Everton forward Richarlison - headed home a final goal to put the game to bed.
Jake O'Brien thought he had levelled the tally a short while after the defender's opener, glancing a powerful header past the Spurs keeper from an Everton corner.
Beto, in the meantime, missed a number of opportunities, while the Italian goalkeeper made a succession of fine saves to guarantee Tottenham went five away games unbeaten in the Premier League.
But the VAR intervened, advising the match official to review the score on the pitchside monitor and the official ruled that the winger and the attacker were in offside positions and had impeded with the Spurs keeper.
This victory moves the manager's side into third place in the Premier League, five points off north London rivals and leaders the Gunners.
Everton remain in 14th position and are half a dozen points ahead of the relegation zone.
Following a drab midweek display in the Champions League against the French side, where they managed a mere attempts on target, the manager chose Randal Kolo Muani up front instead of former Toffees player Richarlison.
The new arrival was unable to influence the game before being replaced for the substitute after an hour on the pitch, but it emerged he wasn't needed in the final outcome.
Centre-back the Dutchman converted into an attacking force to be reckoned with.
Spurs' first goal came from a cleverly executed set-piece play, with Rodrigo Bentancur directing the ball toward the face of goal for an unmarked the defender to head home.
And the captain - filling in as skipper in Cristian Romero's absence - added his second in added time as he rose above Jordan Pickford to head home.
Van de Ven was just as outstanding in defence, combining effectively with his defensive colleague as the duo dealt superbly with the numerous deliveries thrown their way by Everton.
Everton's new home had been a happy hunting ground, but it appears the freshness may have worn off slightly and supporters flocked to the exits after the midfielder's final goal for Tottenham.
The end in the team's winning streak at home will not be a massive concern for David Moyes, but their attacking woes will be.
The forward and the other striker - the Everton's pair of established strikers - had netted just a single goal between them before the weekend's match.
And they were failed to contribute to that miserable tally on a wet and gloomy night on Merseyside.
The striker's performance was epitomized when he opted to bicycle-kick a golden opportunity from near the goal, even with having room and opportunity to readjust for a more conventional shot that would have tested the keeper.
The substitute, as well, was unable to influence the game after replacing Beto in the 65th minute.
It wasn't for a lack of opportunity. The majority of Everton's offensive moves came through the winger and Ndiaye, who tirelessly whipped dangerous crosses into the Spurs penalty area.
Everton: The team head to the Stadium of Light in the Premier League on early November at 20:00 GMT.
Spurs: Spurs go to Newcastle's ground on Wednesday, 29 October for their next round Carabao Cup match against Newcastle.
A passionate linguist and writer dedicated to helping others improve their communication through creative storytelling.